The use of two-piece capsules in dry powder inhalers (DPI’s) is a well-established method of dosing medicines into the lungs, especially in the treatment of pulmonary and systemic diseases.
Two-piece capsules are chosen for DPI application because they:
Are a relatively inert carrier for powders
Can be filled with small quantities
Are easy to use in a breath-actuated device
Are simple to format to reduce development times
The Qualicaps
®
Group understands the unique properties required of a two-piece capsule for inhalation applications. Two-piece capsules offer the extra specifications needed to make DPI applications successful.
Gelatin Capsules
The market standard for many years
High-quality product which matches the stringent requirements of the pharmaceutical industry
Special manufacturing process to meet specifications for inhalation
Improved microbiological purity, particularly relevant as powder is delivered directly into the lungs
Good powder release from capsule shell
Tighter weight specification available
Quali-V
®
Capsules
Hypromellose capsules made from plant-derived materials
Proven pharmaceutical performance
Meets all compendial dissolution requirements
Moisture content 4.5% to 6.5%
Better cutting and puncturing performance
Fewer shell particles generated in use
Excellent microbiological quality
Less prone to static charging; reduced powder adhesion and more uniform dosing
Tighter weight specification available
Ideal for new inhalation drug development
Since Qualicaps
®
produces both capsules and equipment, we are able to offer unmatched suitability between our capsule products and the
equipment
that fills and seals them.
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