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The majority of solid oral dosage formulations filled into two-piece capsules are simple powder mixtures, but capsules are also an ideal container for unit doses of tablets, mini-tablets, pellets and granules. The filling of two-piece capsules with multi-particulates has a significant advantage over compressing them into tablets, as the process maintains their individual coat integrity without any risk of damage.
The Qualicaps
®
Group manufactures two-piece capsules for solid oral dosage forms in gelatin and Quali-V
®
(hypromellose). Each material offers advantages for specific applications.
Gelatin Capsules
The market standard for many years
High-quality product which matches the stringent requirements of the pharmaceutical industry
Excellent performance on high-speed capsule filling machines
Available worldwide
Available in a wide range of sizes, colors and imprints
Quali-V
®
Capsules
Hypromellose capsules made from plant-derived materials
Proven pharmaceutical performance
Meets all compendial dissolution requirements
Compatible with a wider range of excipients than gelatin
Ideal for new drug development
The formulation and filling of hard capsules is a simple process and thus the validation and analytical costs are significantly less than that for other solid oral dosage forms. In addition, capsules offer the following benefits:
Good dissolution for properly-formulated products
Fewer problems in scale-up compared to tablets
Reduce development workload through simple formulations and manufacturing processes
Since Qualicaps
®
produces both capsules and equipment, we are able to offer unmatched suitability between our capsule products and the
equipment
that fills and seals them.
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